In some animals, such as the guinea pig and cat, soleus consists of 100% slow muscle fibers. 2:99. doi: 10.3389/fgene.2011.00099 Skeletal muscle is the main tissue of lipid metabolism and accordingly is critical for homeostasis and energy production; however, the determinants of lipid accumulation in skeletal muscle are unknown. Mouse soleus muscles were denervated by crushing the soleus nerve where it enters the muscle to determine if denervation followed by self-reinnervation can permanently alter the mix of fiber types in a muscle. In: Journal of Muscle Research and Cell Motility. We evaluated the soleus muscles of 37 wild-type mice at 2, 4, 8, and 12 weeks after injury. Soleus muscles have a higher proportion of slow muscle fibers than many other muscles. The soleus muscle has a large portion of type I fibers of approximately 40% in wild-type mice . In line with previous studies (Greising et al., 2013; Omairi et al., 2016), we found that, irrespective of age, the mouse soleus contains mostly type I and IIa fibers, whereas the EDL is predominantly composed of type IIb fibers and the diaphragm has primarily type IIa and type IIx fibers. Front. Here, we examined whether the soleus muscle (predominantly slow-twitch fibers) has a higher lipid accumulation capacity than that of the extensor digitorum longus (EDL, predominantly fast … Before feeding, the mouse soleus muscle was composed of approximately 70% type I and 30% type IIa (as our present PCR analysis indicated a more than 100‐fold higher expression level of IIa than that of IIb or IId, type IIa fibers are considered to be predominant in the mouse soleus muscle… Finally, we also used a Myh7 (type I myosin) promoter-driven Cre mouse line to delete Mapk1 and Mapk3 in existing slow muscle fibers, of which the soleus muscle has the largest density. Keywords: skeletal muscle, muscle fiber types, genetic variation. 2017 ; … The muscles studied here have been stained for slow myosin heavy chain (Type I). / Mouse soleus (slow) muscle shows greater intramyocellular lipid droplet accumulation than EDL (fast) muscle : fiber type-specific analysis. Mouse Strain Dependent Differences in Muscle Fiber Type, Fiber Area, and Blood Perfusion in Response to Denervation Atrophy ... to approximately 46% (in the gastrocnemius) depending on muscle. Skeletal Muscle Fiber Type Conversion during the Repair of Mouse Soleus: Potential Implications for Muscle Healing after Injury Tetsuya Matsuura,1,2 Yong Li,1,2 Jean-Paul Giacobino,1,2 Freddie H. Fu,1 Johnny Huard1,2 1Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 2Stem Cell Research Center, Children’s Hospital of Pittsburgh, 3460 Fifth Avenue, Average fiber size of the TA and soleus decreased after denervation, but no difference was found between strains. Gene. [6] [7] Human soleus fiber composition is quite variable, containing between 60 and 100% slow fibers. We used a mouse model of cardiotoxin injury to examine fiber type conversion during muscle repair. This proportion is close to the value obtained with the software (Figure 9E), however there was a large increase in the percentage of slow fibers in the mdx soleus muscle. Citation: Carroll AM, Palmer AA and Lionikas A (2012) QTL analysis of type I and Type IIA fibers in soleus muscle in a cross between LG/J and SM/J mouse strains.
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